@article{Ethemoglu_Yilmaz_Kavalci_Akman_Terzioglu_Sahin Kavakli_Erel_Senat_Koca_2018, title={A Comparison of Thiol/Disulphide Levels of Workers in Operating Rooms and Emergency Healthcare Centers: Thiol / disulphide levels of workers in operating rooms and emergency healthcare centers}, volume={49}, url={https://actamedica.org/index.php/actamedica/article/view/295}, DOI={10.32552/2018.ActaMedica.295}, abstractNote={<p class="p1"><span class="s1">Objective: Thiol/disulphide homeostasis has a crucial role for life. The aim of this study was to compare thiol/disulphide homeostasis in healthcare professionals working in the operating room (Group 1) and healthcare professionals working in the emergency department (Group 2).</span></p> <p class="p1"><span class="s1">Materials-Methods: This was a descriptive study. Fortynine operating room volunteers (Group 1) and 49 emergency department volunteers (Group 2) were included in this study. Thiol and disulphide concentrations were measured using the novel automated measurement method developed by Erel & Neşelioğlu in 2014.</span></p> <p class="p1"><span class="s1">Result: The thiol/disulphide levels were compared in both groups; Native thiol in group 1 was 353,57 ± 49,86 μmol.L<sup>-1</sup>, and it was<span class="Apple-converted-space">  </span>333,73 ± 37,38 μmol.L<sup>-1</sup> (p = 0.028) in group 2. total thiol values were 384,71 ± 52,36 μmol.L⁻¹ and 370,94 15,56 ± 5,36 μmol.L<sup>-1</sup>(P =0,133), respectively in group 1 and 2. In group 1,disulphide levels were<span class="Apple-converted-space">  </span>15,56±5,36 μmol.L<sup>-1</sup>,<span class="Apple-converted-space">  </span>in<span class="Apple-converted-space">  </span>group 2 it was<span class="Apple-converted-space">  </span>18,61 ± 7,71 μmol.L<sup>-1</sup> (p = 0,025), disulphide/native thiol in<span class="Apple-converted-space">  </span>group 1 was 4,47 ± 1 %, and in<span class="Apple-converted-space">  </span>group 2 it was measured %, 5,73 ± 2,95% (p = 0.009). Disulphide/total thiol in the group 1 was 4,06 ± 1,32% and 5,03 ± 2,13% (p = 0,008) in group 2. Native thiol / total thiol levels were 90,23 ± 12,16% in group 1<span class="Apple-converted-space">  </span>and 89,93 ± 4,26% in<span class="Apple-converted-space">  </span>group 2 (p = 0,871). Native thiol level in group 1 and high level of disulphide in group 2 indicate that the exposure to oxidative stress in the emergency department is higher than in the operating room.</span></p> <p class="p1"><span class="s1">Conclusion: Our results show that participants of emergency room group have statistically higher levels of disulphide than participants working in operating room which may suggest presence of oxidative stress related with workplace exposures.</span></p> <p class="p2"> </p> <p class="p1"><span class="s1">Key Words: Health personnel, oxidative stress, thiol/disulphide homeostasis.</span></p> <p class="p1"> </p> <p class="p1"> </p>}, number={3}, journal={Acta Medica}, author={Ethemoglu, Filiz Banu and Yilmaz, Hidir and Kavalci, Gulsum and Akman, Cem and Terzioglu, Nurkan and Sahin Kavakli, Havva and Erel, Ozcan and Senat, Almila and Koca, Ayca}, year={2018}, month={Sep.}, pages={1–9} }