@article{Gülseren_Bostan_Doğan_Yalıcı-Armağan_Akdoğan_Ersoy-Evans_Elçin_Karaduman_Atakan_2020, title={Lactate dehydrogenase, Beta-2 Microglobulin Levels and CD4/CD8 Lymphocyte Ratio in Patients with Mycosis Fungoides in Stage 1A}, volume={51}, url={https://actamedica.org/index.php/actamedica/article/view/503}, DOI={10.32552/2020.ActaMedica.503}, abstractNote={<p><strong>Objective:</strong> Mycosis fungoides is the most common type of primary cutaneous T-cell lymphomas. In this study, we aimed to investigate the biochemical parameters of beta-2 microglobulin, lactate dehydrogenase, CD4/CD8 lymphocyte ratio determined by flow cytometry, and T cell clonality in patients with MF and to correlate these parameters in stage 1A and other stages.</p> <p><strong>Materials and Methods:</strong> A hundred sixty-one (87 Male, 74 Female) patients followed-up between January 1995 and January 2019 were retrospectively evaluated. Patients’ demographics, stage of the disease, peripheral lymph node and organ involvement, peripheral blood beta-2-microglobulin, lactate dehydrogenase levels, CD4/CD8 + lymphocyte ratio and presence of T cell clonality in biopsy samples were evaluated.</p> <p><strong>Results:</strong> Median beta-2 microglobulin levels were 1608.5 ng/ml for stage 1A and 1970.5 ng/ml for other stages. Peripheral blood median CD4/CD8 lymphocte ratio was 1.60 for stage 1A and 1.85 for other stages. We found statistically significant difference between two groups in terms of beta-2 microglobulin levels and peripheral blood median CD4/CD8 lymphocte ratio (p=0.001, p=0.04). No statistically significant difference was found between two groups in terms of lactate dehydrogenase levels and T-cell clonality (p=0.234, p=0.525).</p> <p><strong>Conclusion:</strong> Our study supports that high peripheral blood beta-2 microglobulin level and CD4/CD8 lymphocyte ratio at the time of diagnosis may imply advanced stage and poor prognosis in Mycosis Fungoides.</p>}, number={4}, journal={Acta Medica}, author={Gülseren, Duygu and Bostan, Ecem and Doğan, Sibel and Yalıcı-Armağan, Başak and Akdoğan, Neslihan and Ersoy-Evans, Sibel and Elçin, Gonca and Karaduman, Ayşen and Atakan, Nilgün}, year={2020}, month={Dec.}, pages={16–21} }