@article{Dikmetaş_Lotfisadigh,_Kaşıkçı_Çankaya_Kocabeyoğlu_2021, title={The Results of Trabeculectomy with Antimetabolites in Elderly Patients: A Retrospective Study}, volume={52}, url={https://actamedica.org/index.php/actamedica/article/view/582}, DOI={10.32552/2021.ActaMedica.582}, abstractNote={<p><strong>Objective:</strong> To examine the effectiveness and results of primary trabeculectomy with 5-fluorouracil (group 1) or mitomycin-C (group 2) in elderly patients.</p> <p><strong>Materials and Methods:</strong> This was a retrospective study including 67 eyes with primary open-angle glaucoma that underwent primary trabeculectomy with group 1 or group 2. Patients who were followed up for less than 1 year or were under 55 years of age were excluded from the study. Surgical success was evaluated according to a decrease in cup/disk ratio and reduction of intraocular pressure without any topical medication.</p> <p><strong>Results:</strong> The mean ages of participants were 65.7 years (range 59–88) and 65.9 years (range 59–74) in groups 1 and 2, respectively. The mean preoperative and postoperative intraocular pressure values were 31.3 ± 5.7 mmHg (range 17–46) and 14.8 ± 0.4 mmHg (range 10–21) in group 1 (p < 0.001) and 31.5 ± 7.4 mmHg (range 18–52) and 14.8 ± 2.9 mmHg (range 10–21) in group 2 (p < 0.001).</p> <p><strong>Conclusion:</strong> The use of 5-fluorouracil or mitomycin-C during primary trabeculectomy is associated with high postoperative success rates. There were no significant differences between 5-fluorouracil and mitomycin-C in terms of intraocular pressure reduction.</p>}, number={2}, journal={Acta Medica}, author={Dikmetaş, Özlem and Lotfisadigh, Sepideh and Kaşıkçı, Merve and Çankaya, Ali Bülent and Kocabeyoğlu, Sibel}, year={2021}, month={Apr.}, pages={162–166} }