TY - JOUR AU - Oymak, Yeşim AU - Geter, Süleyman AU - Ayçiçek, Ali PY - 2014/01/20 Y2 - 2024/03/29 TI - Clinical Outcomes of Childhood Leukemia with Hyperleukocytosis, without Leukopheresis JF - Acta Medica JA - Acta Medica VL - 45 IS - 1 SE - Original Article DO - UR - https://actamedica.org/index.php/actamedica/article/view/158 SP - 89-94 AB - <div class="column"><p>Introduction: The condition of hyperleukocytosis in acute leukemia is an emergency situation; however, there is still controversy about whether leu- kopheresis is a superior treatment in preventing early mortality.</p><p>Aim: The purpose of this study was to evaluate the early mortality rates in pediatric leukemia patients with hyperleukocytosis who recieved a conven- tional cytoreduction method in a healthcare center.<br> Methods: The files of 25 pediatric acute leukemia patients with hyperleuko- cytosis, diagnosed at Harran University Pediatric Hematology Department between January 2005 and December 2012, were evaluated retrospectively. The clinical and laboratory findings were recorded. Treatments using cytore- duction, with or without methylprednisolone, were evaluated in terms of ear- ly mortality rate and duration of treatment for cytoreduction.</p><p>Results: The early mortality rate (12.0%) in our center was similar to that of other centers with the ability to treat patients with leukopheresis (3.8-16%). Cytoreduction with methylprednisolone is a faster treatment method than that without methylprednisolone. Also there were no differences between the patients who survived and were lost in terms of duration for cytoreduction. Conclusion: Hyperleukocytosis in acute leukemia is considered as an emer- gency situation and should be managed promptly. Conventional methods for cytoreduction can be used with a similar early mortality rate of the centers with the ability to use leukopheresis.</p></div> ER -