TY - JOUR AU - Dikmetaş, Özlem AU - Lotfisadigh,, Sepideh AU - Kaşıkçı, Merve AU - Çankaya, Ali Bülent AU - Kocabeyoğlu, Sibel PY - 2021/04/25 Y2 - 2024/03/28 TI - The Results of Trabeculectomy with Antimetabolites in Elderly Patients: A Retrospective Study JF - Acta Medica JA - Acta Medica VL - 52 IS - 2 SE - Original Article DO - 10.32552/2021.ActaMedica.582 UR - https://actamedica.org/index.php/actamedica/article/view/582 SP - 162-166 AB - <p><strong>Objective:</strong> To examine the effectiveness and results of primary trabeculectomy with 5-fluorouracil (group 1) or mitomycin-C (group 2) in elderly patients.</p><p><strong>Materials and Methods:</strong> This was a retrospective study including 67 eyes with primary open-angle glaucoma that underwent primary trabeculectomy with group 1 or group 2. Patients who were followed up for less than 1 year or were under 55 years of age were excluded from the study. Surgical success was evaluated according to a decrease in cup/disk ratio and reduction of intraocular pressure without any topical medication.</p><p><strong>Results:</strong> The mean ages of participants were 65.7 years (range 59–88) and 65.9 years (range 59–74) in groups 1 and 2, respectively. The mean preoperative and postoperative intraocular pressure values were 31.3 ± 5.7 mmHg (range 17–46) and 14.8 ± 0.4 mmHg (range 10–21) in group 1 (p &lt; 0.001) and 31.5 ± 7.4 mmHg (range 18–52) and 14.8 ± 2.9 mmHg (range 10–21) in group 2 (p &lt; 0.001).</p><p><strong>Conclusion:</strong> The use of 5-fluorouracil or mitomycin-C during primary trabeculectomy is associated with high postoperative success rates. There were no significant differences between 5-fluorouracil and mitomycin-C in terms of intraocular pressure reduction.</p> ER -