Non-transfusion dependent thalassemia (NTDT) defines thalassemic patients who do not require regular transfusions for survival. However, these patients are still at risk for iron loading related to primarily increased iron absorbtion through intestines. Herein, the iron accumulation mechanisms, complicatrions and management of iron loading in patients with NTDT were summarized. Key words: NTDT, iron, chelation, LIC