Vitamin D and Parathyroid Hormone Levels in Prediction of the Prevalence of Cerebrovascular Accident in Geriatric Patients

Abstract

Background: Plasma 25- (OH) Vitamin D level and various disorders such as metabolic syndrome, type 2 diabetes mellitus, cardiovascular problems, dementia, chronic renal disease, chronic pulmonary disease, colorectal can- cer were shown to be associated. However, recent studies indicate that para- thyroid hormone (PTH) may also have an impact on the development of aforementioned disorders. In this study, we aimed to investigate plasma vi- tamin D and serum PTH status and cerebrovascular accident association in the elderly.

Material and Methods: Totally, 1078 adult patients aged 65 year-old or old- er (103 patients with a past medical history of stroke and 975 patients with- out stroke history) were included in this cross sectional study. After compre- hensive geriatric assessment, laboratory investigations including plasma vi- tamin D and serum PTH levels were evaluated.

Results: The median of plasma 25- (OH) Vitamin D levels (16.28 vs. 18.00 ng/ml) was significantly lower and the median of serum PTH levels (58.7 vs. 54.9 pg/ml) was significantly higher in patients with stroke than in patients without his- tory of stroke group (P=0.016 and P=0.019, respectively). Multivariate regres- sion analysis revealed that only serum PTH level (OR=1.007, 95% CI=1.002- 1.012, P=0.007) was an independent variable for stroke.

Conclusion: Our study supports the assumption that elevated PTH has a role in stroke risk stratification. We would like to emphasize that serum PTH level -even though it is in the reference range- may be a predictor of cardio- vascular outcomes such as cerebrovascular accident in the elderly.