Genome Editing Technologies: From Bench Side to Bedside

Review

  • Fulya Yaylacıoğlu Tuncay
  • Pervin Rukiye Dinçer

Abstract

The development of genome editing technologies has given the chance to researchers to manipulate any genomic sequences precisely. This ability is very useful for creating animal models to study human diseases in vivo; for easy creation of isogenic cell lines to study in vitro and most importantly for overcoming many disadvantages that the researchers faced during the human gene therapy trials. Here we review the basic mechanisms of genome editing technology and the four genome-editing platforms. We also discuss the applications of these novel technologies in preclinical and clinical studies in four groups according to the mechanism used, and lastly, summarize the problems in these technologies.

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Published
Sep 30, 2018
How to Cite
YAYLACIOĞLU TUNCAY, Fulya; DINÇER, Pervin Rukiye. Genome Editing Technologies: From Bench Side to Bedside. Acta Medica, [S.l.], v. 49, n. 3, p. 30-40, sep. 2018. ISSN 2147-9488. Available at: <https://actamedica.org/index.php/actamedica/article/view/282>. Date accessed: 22 oct. 2018. doi: https://doi.org/10.32552/2018.ActaMedica.282.
Section
Review