Potential Impacts of Gut Microbiota On Immune System Related Diseases: Current Studies and Future Challenges

Abstract

Human microbiota includes trillions of cohabitant microorganisms in a symbiotic relationship. They directly or indirectly communicate with immune system. Human microbiome profiling studies has accelerated microbiota studies and interest to microbiota and disease relationship . Some metabolic activities of human microbiota were known, but in recent years many different roles in addition to metabolic activities, have been shown. It can affect systems and mechanisms, and most importantly clinical course of diseases in dysbiosis condition, and reduces most symptoms when symbiosis is provided. These features make microbiota a potential therapeutic tool or biomarker  for a spate of disease in clinic applications.This review summarizes host- gut microbiota interaction, role of microbiota in immune-related diseases, and potential therapeutic  approaches.

Keywords: Gut microbiota, microbiome, immune system related disease