Fibromyalgia Prevalence and its Association with Laboratory Parameters in Patients with Chronic Renal Failure: A Single-Centered Study from Turkey

Chronic Renal Failure and Fibromiyalgia

Abstract

Backround:  This study aimed to evaluate the prevalence of fibromyalgia syndrome in patients with chronic renal failure  and evaluate the association of this syndrome with gender, age, hemodialysis , and laboratory parameters.

Patients and Method: The study was designed as cross-sectional prospective clinical study. A total of 135 patients with chronic renal failure were included in the study; 65 of the patients participating in the study were randomly selected from the ones who were diagnosed with grade 3–4 chronic renal failure and were under clinical follow-up. 

Results: Of the 135 patients who participated in the study, 74 (55.8%) were female and 61 (45.2%) were male. Eighteen of the seventy (25.7%) patients who were diagnosed with fibromyalgia syndrome were in the hemodialysis group and 12/65 (18.4%) were in the predialysis group. The Fibromyalgia impact questionnaire  result was 66.2 ± 15.01 in the dialysis group (N = 18) and 65.45 ± 4.17 in the predialysis group (N = 12). In the predialysis group, low vitamin D (p= 0.000), high acute-phase reactant (p= 0.00) and high uric acid levels (p=0,001) were detected. Statistically significant high thyroid-stimulating hormone and aspartate aminotransferase values were found with the presence of  fibromyalgia syndrome in both the groups. The logistic regression analysis (analysis of variance) revealed that vitamin D had a high predictive value for the presence of fibromyalgia syndrome in the predialysis group (beta = 0.42, p= 0.001, confidence interval 0.41).

Conclusion: Systemic disorders such as hypothyroidism, vitamin D deficiency, and inflammation may also contribute to the development of fibromyalgia syndrome in chronic renal failure patients.

Keywords: Fibromyalgia, chronic renal failure, hemodialysis

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