Comparison of the effects of intravenous analgesic agents used in the intraoperative period on pentraxin-3 levels in patients undergoing on-pump coronary artery bypass surgery

Abstract

Objective: The aim of this study was to compare the effects of fentanyl, dexmedetomidine, and remifentanil on serum pentraxin 3 levels in patients undergoing on-pump coronary artery bypass surgery.

Materials and Methods: In this retrospectively designed study, 36 patients who underwent elective on-pump coronary artery bypass surgery for coronary artery disease in the Cardiovascular Surgery Clinic of our hospital between 01.01.2020 and 31.12.2021 and whose serum pentraxin 3 levels were studied in the pre-operative and post-operative period were included. Patients were divided into 3 groups as fentanyl (Group F), dexmedetomidine (Group D), and remifentanil (Group R) based on the analgesic agent used during the intraoperative period. The data of the patients were obtained by scanning their files and information in the hospital automation system.

Results: Demographic characteristics, duration of anesthesia, cardiopulmonary bypass duration, and aortic cross-clamp duration were similar. When serum pentraxin 3 levels were evaluated within groups, the difference between pre-operative and post-operative results was significant. In the intergroup evaluation, only the results obtained from Group F in the pre-operative period were significant compared to the other groups, but there was no significant difference between the results obtained in the post-operative period.

Conclusion: When the data of this study were evaluated, it was determined that the analgesic agent used in the intraoperative period of on-pump coronary artery bypass surgery did not significantly affect post-operative serum pentraxin 3 levels.