Central nervous system involvement of chronic lymphocytic leukaemia: A rare case report

Derya Koyun; Kurtuluş Umut Bozkurt; Nıjat Abbaszade; Rezzak Yılmaz; Pervin Topçuoğlu

doi:10.32552/2024.ActaMedica.994

Authors

Derya Koyun Department of Hematology, School of Medicine, Ankara University, Ankara, Türkiye https://orcid.org/0000-0003-3970-2010
Kurtuluş Umut Bozkurt Department of Neurology, School of Medicine, Ankara University, Ankara, Türkiye https://orcid.org/0009-0006-3666-2200
Nıjat Abbaszade Department of Neurology, School of Medicine, Ankara University, Ankara, Türkiye https://orcid.org/0009-0006-4266-5440
Rezzak Yılmaz Department of Neurology, School of Medicine, Ankara University, Ankara, Türkiye https://orcid.org/0000-0002-0367-4102
Pervin Topçuoğlu Department of Hematology, School of Medicine, Ankara University, Ankara, Türkiye https://orcid.org/0000-0002-6796-5873

DOI:

https://doi.org/10.32552/2024.ActaMedica.994

Keywords:

chronic lymphocytic leukemia, central nervous system, cerebralspinal fluid

Abstract

Central nervous system (CNS) involvement in chronic lymphocytic leukemia (CLL) is unfamiliar. The diagnosis is delayed commonly, because of underdiagnosis or subclinical symptoms. We describe a 80-year-old woman with a previous diagnosis of CLL who presented to the emergency service with tonic clonic seizure. The new therapies, eg, ibrutinib and venetoclax, can be effective treatment strategies for CLL with CNS involvement. In our case, treatment with ibrutinib led to a resolution of the cerebralspinal fluid (CSF) neoplastic infiltration, but the patient died afterwards.

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Central nervous system involvement of chronic lymphocytic leukaemia: A rare case report

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